Hamilton’s paramedics are on the frontlines of the Canadian opioid crisis, witnessing its deep impacts and toll on a daily basis. The crisis is escalating, and immediate intervention is needed to save lives. Efforts are being made to combat the crisis, but more needs to be done through collaboration, distribution of naloxone, and comprehensive treatment strategies. A call to action is needed from civic and community leaders to support initiatives and implement fresh ideas to effectively address the crisis. The work to combat the opioid crisis is a shared responsibility that requires collective attention and action.